Researchers at the Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), working in collaboration with colleagues at other centers in Spain and abroad, have identified defects in the hearts of progeria patients that appear to be related to an elevated risk of arrhythmias and premature death. The study, published the Proceedings of the National Academy of Sciences (PNAS), shows that these risks are linked to anomalies in the transmission of electrical signals in the hearts of individuals with Hutchinson-Gilford progeria syndrome (HGPS), also known as progeria. Similar findings were observed in a mouse model of the disease The findings of this study open the way to research into new treatments to correct these characteristic defects. The study could also provide clues about the mechanisms involved in the development of cardiovascular disease during normal aging.
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